It is widely accepted that activated microglia exert dual functions, that is, pro-inflammatory (M1) and anti-inflammatory (M2) Minocycline is a semisynthetic, second‐generation tetracycline derivative which crosses the blood–brain barrier and may inhibit microglial‐related inflammatory events and also
Moreover, the dose used in our present study, 45
In particular, the microglial inhibitor, minocycline, has been shown to attenuate learning and memory deficits in several neurodegenerative diseases
by
Matrix metalloproteinases (MMPs) have been studied extensively, and MMP inhibitors have been used as dental pretreatment agents prior to dentin bonding
CYP3A4 is the most important of the CYP450 enzymes for drug metabolism and for drug interactions
Beta-lactamase inhibitors are drugs that are co-administered with beta-lactam antimicrobials to prevent antimicrobial resistance by inhibiting serine beta-lactamases, which are enzymes that inactivate the beta-lactam ring, which is a common chemical structure to all beta-lactam antimicrobials
Many publications on MMP-9 inhibitors report that minocycline, azithromycin and bortezomib possess one or several of the above capacities
72 ± 0
The results of the present research have shown that single and repeated administrations of the glial cell inhibitor minocycline, used alone or in combination with ambroxol or duloxetine, might attenuate pain due to an oxaliplatin injection
Repotrectinib
Minocycline for preventing EGFR inhibitor-induced rash
Minocycline was reported to be generally used as a selective microglial/macrophage inhibitor
In particular, the antibiotic minocycline, an inhibitor of bacterial ribosomal rRNA, showed the highest binding affinity (-9
Here we show EGFR inhibitor drugs induce the expression of specific chemokines (CCL2, CCL5, CCL27, and CXCL14) in epidermal keratinocytes, and impair the production of antimicrobial peptides and skin barrier proteins
Minocycline and doxycycline are semisynthetic tetracycline derivatives, which exert several anti-inflammatory effects independent of their anti
Pyrazinamide (PZA) is currently the gold standard broad mechanism inhibitor for Mtb and is a major component of the first-line antibiotic cocktail used for Mtb treatment
Abstract
Dilution Methods
While much attention has been focused on mGluR5 inhibitors as a potential avenue of disease treatment [31, 45–47], a significant amount of new evidence from Drosophila , mouse , and human studies [52, 54] suggests that the common tetracycline derivative minocycline may be a new and highly effective treatment